Depression - page 6 Scientific Publications

Latest publication 04/02/2008

Lasting Syndrome of Depression Produced by Reduction in Serotonin Uptake during

Dysfunction of the serotonin system is implicated in sleep and emotional disorders. To test whether these impairments could arise during...

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    [title] => Lasting Syndrome of Depression Produced by Reduction in Serotonin Uptake during 
    [paragraph] => Lasting Syndrome of Depression Produced by Reduction in Serotonin Uptake during Postnatal Development: Evidence from Sleep, Stress, and Behavior.
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Authors
D. Popa, C. Léna, C. Alexandre, J. Adrien.

 Lab
Université Pierre et Marie Curie-Paris 6, Unité Mixte de Recherche S677, Paris, France ; Institut National de la Santé et de la Recherche Médicale U677, Neuropsychopharmacologie, Paris, France.
Journal
The Journal of Neuroscience
Abstract
Dysfunction of the serotonin system is implicated in sleep and emotional disorders. To test whether these impairments could arise during development, we studied the impact of early-life, transient versus genetic, permanent alterations of serotonin reuptake on sleep–wakefulness patterns, depression-related behavior, and associated physiological features. Here, we show that female mice treated neonatally with a highly selective serotonin reuptake inhibitor, escitalopram, exhibited signs of depression in the form of sleep anomalies, anhedonia, increased helplessness reversed by chronic antidepressant treatment, enhanced response to acute stress, and increased serotoninergic autoinhibitory feedback. This syndrome was not reproduced by treatment in naive adults but resembled the phenotype of mutant mice lacking the serotonin transporter, except that these exhibited decreased serotonin autoreceptor sensitivity and additional anxiety-like behavior. Thus, alteration of serotonin reuptake during development, whether induced by external or genetic factors, causes a depressive syndrome lasting into adulthood. Such early-life impairments might predispose individuals to sleep and/or mood disorders.
BIOSEB Instruments Used
Tail Suspension Test - Wireless (BIO-TST5)
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Bioseb's version 5 of the Tail Suspension Test system, based on both strain sensors and video acquisition, is the only fully automatic solution in the world for running a simple and objective despair test on mice. It is a fast, painless, and reliable way for testing psychotropic effects from stimulant doses of drugs such as anti-depressants and sedatives. This classic and painless research test for anxiety and depression is now offered with a new, powerful and modern software, in a wireless, bluetooth-based version.

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