Parkinson disease - page 3 Scientific Publications

Latest publication 05/15/2013

Bilateral lesions of the nigrostriatal pathways are associated with chronic mech

Some patients with Parkinson's disease (PD) suffer from pain before motor symptoms. To model this, we proposed to assess the mechanical...

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    [title] => Bilateral lesions of the nigrostriatal pathways are associated with chronic mech
    [paragraph] => Bilateral lesions of the nigrostriatal pathways are associated with chronic mechanical pain hypersensitivity in rats
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Authors
Y. Zengin-Toktas, J. Ferrier, F. Durif, PM. Llorca et N. Authier.

 Lab
 INSERM 1107, NEURO-DOL, Clermont-Ferrand, France
Journal
Neuroscience Research
Abstract
Some patients with Parkinson's disease (PD) suffer from pain before motor symptoms. To model this, we proposed to assess the mechanical hypersensitivity in an animal model of PD with a bilateral lesion of the nigrostriatal pathway. PD model was validated by a decrease of locomotor activity and a 76% dopamine cell loss in the substantia nigra pars compacta. PD animals displayed a decrease of mechanical thresholds, correlated with the degree of the dopamine lesion. This animal model displays nociceptive disorders as found in PD patients and could be useful to assess the effects of new antiparkinsonian drugs.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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