Publications

Latest publication 02/01/2025

IĸBζ as a Central Modulator of Inflammatory Arthritis Pathogenesis

Current therapies targeting individual factors in inflammatory arthritis show variable efficacy, often requiring treatment with combinations of...

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    [title] => IĸBζ as a Central Modulator of Inflammatory Arthritis Pathogenesis
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Authors
Gaurav Swarnkar, Musarrat Naaz, Dorothy Mims, Prashant Gupta, Timothy Peterson, Matthew J. Christopher, Srikanth Singamaneni, Gabriel Mbalaviele, Yousef Abu-Amer

 Lab

Journal
Arthritis & Rheumatology
Abstract
Current therapies targeting individual factors in inflammatory arthritis show variable efficacy, often requiring treatment with combinations of drugs, and are associated with undesirable side effects. NF-ĸB is critical for the production and function of most inflammatory cytokines. However, given its essential role in physiologic processes, targeting NF-ĸB is precarious. Hence, identifying pathways downstream of NF-ĸB that selectively govern the expression of inflammatory cytokines in inflammatory arthritis would be advantageous. We have previously identified IĸBζ as a unique inflammatory signature of NF-ĸB that controls the transcription of inflammatory cytokines only under pathologic conditions while sparing physiologic NF-ĸB signals.
Keywords/Topics
Pain ; Arthritis
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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