Publications

Latest publication 07/01/2025

The murine ATP-binding cassette transporter C5 -Abcc5 and MRP5 and cMOAT- plays

ATP-Binding cassette (ABC) transporters are a family of integral membrane ATPases that transport a large number of structurally unrelated...

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    [title] => The murine ATP-binding cassette transporter C5 -Abcc5 and MRP5 and cMOAT- plays 
    [paragraph] => The murine ATP-binding cassette transporter C5 -Abcc5 and MRP5 and cMOAT- plays a role in memory consolidation- circadian rhythm regulation and glutamatergic signalling
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Authors
Banks, Gareth, Cyranka, Malgorzata, Vedovato, Natascia, Meller, Charlotte, Rawnsley, Alex, Mann, Edward O., Stewart, Michelle, de Wet, Heidi

 Lab

Journal
Translational Psychiatry
Abstract
ATP-Binding cassette (ABC) transporters are a family of integral membrane ATPases that transport a large number of structurally unrelated compounds. The physiological role of the orphan transporter Abcc5 remains poorly understood. As previous work demonstrated that the loss of Abcc5 activity leads to elevated levels of NAAG in the brain, the impact of Abcc5 ablation was ascertained using behavioural phenotyping, circadian rhythm analysis and electrophysiological recordings of brain slices from Abcc5−/− mice and compared to wild-type littermates. Behavioural phenotyping of Abcc5−/− mice shows that the loss of murine Abcc5 activity results in profound changes in pre-pulse inhibition (PPI) as well as altered memory consolidation. Circadian measures of activity showed a delay in the timing of Abcc5−/− mice activity rhythm peak. Additionally, activity defined sleep analysis highlighted differences in sleep patterns in Abcc5−/− mice compared to wild-type controls. Patch clamp recording from pyramidal cells in the 2/3 layer of the frontal cortex showed altered synaptic AMPA/NMDA receptor current ratios and increased frequency of spontaneous excitatory postsynaptic currents (sEPSC). This study demonstrates that the loss of functional Abcc5 transporters does have behavioural consequences in mammals and alters NMDA receptor activity. These results highlight a previously unknown role of Abcc5 in the brain.
Keywords/Topics
Learning and memory; Neuroscience
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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