Publications

Latest publication 07/30/2008

Acetaminophen Reinforces Descending Inhibitory Pain Pathways-

The mechanism of the analgesic action of acetaminophen involves the serotonergic system. This study explores how acetaminophen interferes with...

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    [title] => Acetaminophen Reinforces Descending Inhibitory Pain Pathways-
    [paragraph] => Acetaminophen Reinforces Descending Inhibitory Pain Pathways.
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Authors
G. Pickering, V. Estève, M.-A. Loriot, A. Eschalier, C. Dubray.

 Lab
?
Journal
Clinical Pharmacology and Therapeutics
Abstract
The mechanism of the analgesic action of acetaminophen involves the serotonergic system. This study explores how acetaminophen interferes with serotonergic descending pain pathways. Eighteen rapid metabolizers of tropisetron were included in this double-blind cross-over study. After ethical approval, the healthy volunteers took 1 g oral acetaminophen (A) or placebo (p) combined with either the 5-HT3 antagonist tropisetron (T) (5 mg) or saline, intravenously, at weekly intervals. Mechanical pain thresholds, determined before and after a cold pressor test (CPT), were repeated seven times during the three post-dosing hours, and area under the concentration–time curves (AUCs) of the three treatments were compared. After CPT, AUC (%*min) of Ap (1,561±429) was larger than before CPT (393±382, P<0.05); these effects were totally inhibited by tropisetron. Acetaminophen reinforces descending inhibitory pain pathways; it suggests a supraspinal target for acetaminophen’s antinociceptive action. This study also confirmed that there is a central serotonergic mechanism of action for acetaminophen that is not stimulus-dependent.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)

Keywords/Topics
Ischemic Strokes; Pharmacology; Central Nervous System (CNS); Cross-disciplinary subjects 
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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