Joints - page 2 Scientific Publications

Latest publication 10/05/2019

Highly bioavailable curcumin powder suppresses articular cartilage damage in rat

This study was performed to investigate the effects of highly bioavailable curcumin as Theracurmin (TC) in rats with monosodium iodoacetate...

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    [title] => Highly bioavailable curcumin powder suppresses articular cartilage damage in rat
    [paragraph] => Highly bioavailable curcumin powder suppresses articular cartilage damage in rats with mono-iodoacetate (MIA)-induced osteoarthritis
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Authors
HJ Park, CK Lee, SH Song, JH Yun, A Lee, HJ Park

 Lab
Department of Food and Nutrition, Yuhan University, 590 Gyeongin-ro, Bucheon-si, Gyeonggi-do, 14780, Korea
Journal
Food Science and Biotechnology
Abstract
This study was performed to investigate the effects of highly bioavailable curcumin as Theracurmin (TC) in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). Seventy-seven male Wistar rats were divided into six groups: normal, negative control (MIA only), positive control (Cerebrex), and three experimental groups treated with 500, 1300, or 2600 mg/kg of TC for 5 weeks. MIA injection-induced OA caused 30% weight-bearing imbalance whereas weight bearing imbalance was significantly improved in the TC groups. Mankin scores revealed TC treatment had significantly ameliorated cartilage damage and chondrocyte decrease. The expressions of nitrotyrosine, tumor necrosis factor-alpha, phosphorylated nuclear factor kappa B cells, and cleaved caspase-3 were markedly increased in rat with MIA-induced OA, but the TC-treated groups exhibited a significant reduction in the number of immunoreactive cells in a dose-dependent manner. In conclusion, administration of TC contributes to the anti-arthritic effect in rat with MIA-induced OA.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4)
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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