Neuropathic pain - page 5 Scientific Publications

Latest publication 01/19/2019

Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain

It is widely accepted that neuroinflammation in the spinal cord contribute to the development of central sensitization in neuropathic pain. MAPKs...

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    [title] => Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain 
    [paragraph] => Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1
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Authors
Y Gui, S Duan, L Xiao, J Tang, A Li

 Lab
Department of Anesthesiology, Maternal and Child Hospital of Hunan Province, Changsha, China
Journal
Journal of Pain
Abstract
It is widely accepted that neuroinflammation in the spinal cord contribute to the development of central sensitization in neuropathic pain. MAPKs activation plays an vital role in the development of neuroinflammation in the spinal cord. In this study, we investigated the effect of bexarotene, a RXR agonist, on MAPKs activation in CCI-induced neuropathic pain. The data showed that daily treatment with bexarotene 50mg/kg significantly alleviated CCI-induced nociceptive hypersensitivity in rats. Bexarotene 50mg/kg/day inhibited CCI-induced MAPKs (p38MAPK, ERK1/2, and JNK) activation and upregulation of proinflammatory factors(IL-1_, TNF-_ and IL-6). Bexarotene also reversed CCI-induced microglia activation in the ipsilateral spinal cord. Furthermore, bexarotene treatment significantly upregulated MKP-1 in the spinal cord. These effects were completely abrogated by MKP-1 inhibitor BCI. These results indicated that bexarotene relieved CCI-induced neuroinflammation and neuropathic pain by targeting MKP-1. Therefore, bexarotene might be a potential agent for the treatment of neuropathic pain.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)

Keywords/Topics
Neuropathic pain; Pain
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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