Alzheimer disease - page 2 Scientific Publications

Latest publication 07/07/2018

Myostatin Is Associated With Cognitive Decline in an Animal Model of Alzheimer's

With aging, there are progressive functional declines in multiple organ systems. One of the major physiological problems observed in aged people is...

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    [title] => Myostatin Is Associated With Cognitive Decline in an Animal Model of Alzheimer's
    [paragraph] => Myostatin Is Associated With Cognitive Decline in an Animal Model of Alzheimer's Disease
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Authors
L yung-Shuen, L Fang-Yu, H Ya-Hsin

 Lab
College of Medicine, National Cheng Kung UniversityTainanTaiwan
Journal
Molecular Neurobiology
Abstract
With aging, there are progressive functional declines in multiple organ systems. One of the major physiological problems observed in aged people is skeletal muscle loss. This age-related muscle loss causes muscle weakness and disability, which in turn might reduce the quality of life in older adults and lead to the progression of several diseases, particularly Alzheimer’s disease (AD). Some researchers have hypothesized that loss of muscle mass and strength is linked to the risk of developing AD. In addition, unintended weight loss often occurs in AD patients and might reflect dementia severity. However, the causal relationship between muscle atrophy and cognitive deficits in AD is unclear. We found that double transgenic amyloid precursor protein and presenilin 1 (APP/PS1) mice that co-express APP and PS1 at older ages exhibited lower body weight and lean tissue mass than sex- and age-matched wild-type (WT) mice. In addition, muscle atrophy and the extent of memory decline were strongly correlated in APP/PS1 mice. Myostatin levels in the gastrocnemius (GAS) muscle of 12-month-old APP/PS1 mice were elevated. We determined that the cellular and molecular mechanism of muscle atrophy was through the ubiquitin-proteasome pathway. Furthermore, myostatin knockdown in the GAS muscles increased grip strength and muscle mass, leading to memory improvement in myostatin short-hairpin RNA-treated APP/PS1 mice. We conclude that high-level myostatin expression might mediate or trigger muscle atrophy and cognitive deficits.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Alzheimer disease; Muscular atrophy; Neurodegeneration; Muscular system; Infection
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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