Publications

Latest publication 05/29/2022

Conservative analysis of Synaptopodin-2 intron sense-overlapping lncRNA reveals

Dissection of the regulatory pathways that control skeletal muscle development and atrophy is important for the treatment of muscle wasting. Long...

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    [title] => Conservative analysis of Synaptopodin-2 intron sense-overlapping lncRNA reveals 
    [paragraph] => Conservative analysis of Synaptopodin-2 intron sense-overlapping lncRNA reveals its novel function inpromoting muscle atrophy
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Authors
J Jin, M Du, J Wang, Y Guo et al

 Lab
Huazhong Agricultural University, Wuhan, China
Journal
Journal of Cachexia, Sarcopenia and Muscle
Abstract
Dissection of the regulatory pathways that control skeletal muscle development and atrophy is important for the treatment of muscle wasting. Long noncoding RNA (lncRNA) play important roles in various stages of muscle development. We previously reported that Synaptopodin-2 (SYNPO2) intron sense-overlapping lncRNA (SYISL) regu lates myogenesis through an interaction with enhancer of zeste homologue 2 (EZH2). However, it remains unclear whether SYISL homologues exist in humans and pigs, and whether the functions and mechanisms of these homologues are conserved among species.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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