Publications

Latest publication 01/01/2025

Molecular and Functional Recovery in Contused Muscle Tissues Treated with Betuli

Muscle contusion injuries are common in trauma and sports medicine, often resulting in prolonged recovery and functional impairment. This study...

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    [title] => Molecular and Functional Recovery in Contused Muscle Tissues Treated with Betuli
    [paragraph] => Molecular and Functional Recovery in Contused Muscle Tissues Treated with Betulin in Mice
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Authors
Dr. Maria S. Kovalenko, Dr. Elena I. Smirnova

 Lab

Journal
International Research Journal of Medical Sciences and Health Care
Abstract
Muscle contusion injuries are common in trauma and sports medicine, often resulting in prolonged recovery and functional impairment. This study investigates the therapeutic efficacy of betulin—a natural pentacyclic triterpene—on the molecular and functional recovery of skeletal muscle following contusion injury in mice. Using a controlled murine injury model, betulin was administered post-injury, and recovery was evaluated through histological analysis, inflammatory marker profiling, and BIO-GS3ing. The results revealed that betulin significantly reduced inflammation, promoted myofiber regeneration, and accelerated functional recovery compared to untreated controls. Molecular assays demonstrated upregulation of regenerative markers and downregulation of pro-inflammatory cytokines in treated tissue. These findings suggest that betulin facilitates both structural and functional muscle repair and holds promise as a novel therapeutic agent for soft tissue injuries.
Keywords/Topics
Betulin; muscle regeneration; contusion injury; skeletal muscle; inflammation; functional recovery; tissue repair; natural compounds; mice model; triterpenes
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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