Publications

Latest publication 12/01/2018

Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and

Chemotherapy-induced peripheral neuropathic pain is a major limiting factor affecting cancer patients. No effective treatment is currently...

Array
(
    [id_prestablog_news] => 1068
    [id_shop] => 1
    [date] => 2018-12-01 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2097
    [id_lang] => 1
    [title] => Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and
    [paragraph] => Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats
    [content] => 
Authors
X Ba, J Wang, S Zhou, X Luo, Y Peng, S Yang, Y Hao

 Lab
School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, 518060, China
Journal
Biomedicine & Pharmacotherapy
Abstract
Chemotherapy-induced peripheral neuropathic pain is a major limiting factor affecting cancer patients. No effective treatment is currently available. Cinobufacini, an aqueous extract from toad skin, is a widely used anti-cancer drug in China. Clinical evidence has demonstrated the safety and effectiveness of cinobufacini in combination with chemotherapy to promote the therapeutic efficacy while alleviating side effects, especially cancer-related pain symptoms. In this study, the effects of cinobufacini were investigated in a rat model of paclitaxel-induced peripheral neuropathic pain (PIPNP) to better understand and expand its clinical application. A single injection of cinobufacini (2.5_g/kg, i.p.) alleviated pre-established PIPNP, as indicated by decreased mechanical and thermal hypersensitivity compared with paclitaxel-treated rats. Repeated cinobufacini (1.25 and 2.5_g/kg, i.p.), given during the induction of PIPNP, prevented the establishment of paclitaxel-induced mechanical and thermal hypersensitivity. This preventative effect was associated with suppressed paclitaxel-induced TRPV1 up-regulation and spinal astrocyte activation, as well as decreased production of spinal TNF-_ and IL-1_. These findings reveal cinobufacini as a therapeutic potential to treat and prevent paclitaxel-induced peripheral neuropathic pain.
BIOSEB Instruments Used
Cold Hot Plate Test (BIO-CHP)
    [meta_description] => 
    [meta_keywords] => https://www.sciencedirect.com/science/article/pii/S0753332218334449
    [meta_title] => 
    [link_rewrite] => cinobufacini-protects-against-paclitaxel-induced-peripheral-neuropathic-pain-and-suppresses-trpv1-up-regulation-and-spinal-astrocyte-activation-in-rats
    [actif_langue] => 1
    [read] => 1164
    [count_comments] => 0
    [id] => 1068
    [categories] => Array
        (
            [90] => Array
                (
                    [id_prestablog_categorie] => 90
                    [title] => Cancer
                    [link_rewrite] => Cancer
                )

            [24] => Array
                (
                    [id_prestablog_categorie] => 24
                    [title] => Cross-disciplinary subjects 
                    [link_rewrite] => Cross-disciplinary-subjects-
                )

            [48] => Array
                (
                    [id_prestablog_categorie] => 48
                    [title] => Hot & Cold Perception
                    [link_rewrite] => Hot-Cold-Perception
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [13] => Array
                (
                    [id_prestablog_categorie] => 13
                    [title] => Sensory system
                    [link_rewrite] => Sensory-system
                )

        )

    [authors] => 
    [paragraph_crop] => Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [563] => Array
                (
                    [name] => Cold Hot Plate Test
                    [description_short] => 
For testing animal's thermal sensitivity to pain resulting from exposure to heat or cold: the Cold Hot Plate is an innovative instrument opening new investigation fields for your analgesia and nociception research, and a useful tool for analgesic drug screening using rats or mice models.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/pain-thermal-allodynia-hyperalgesia/563-cold-hot-plate-test.html
                )

        )

)
1