Publications

Latest publication 09/01/2017

Impact of SEL1L deletion in central nervous system on the behavior of mice

The Objective was to investigate the role of endoplasmic reticulum protein SEL1L in the maintenance of physiological activities of the central...

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    [title] => Impact of SEL1L deletion in central nervous system on the behavior of mice
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Authors
J Wang, Q Liu, Z Pan, Z Zhou, Q Long

 Lab
Research Center of Laboratory Animals and the Genome Rseearch center of Cambridge-Soochow University, Suzhou, China
Journal
Chinese Journal of Comparative Medicine
Abstract
The Objective was to investigate the role of endoplasmic reticulum protein SEL1L in the maintenance of physiological activities of the central nervous system in mammals. The data of the postnatal survival time, the body weight and the behavioral indicators such as balance coordination, locomotion and anxiety of the mice show that the condition of the NKO mice is significantly worse than that of the WT mice, indicating an important role of SEL1L in the maintenance of physiological functions of the nervous system.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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