Publications

Latest publication 01/25/2021

A Neonatal Mild Defect in Brain Insulin Signaling Predisposes a Subclinical Mode

Brain insulin system dysfunction has been proposed as a key player in the pathogenesis of sporadic AlzheimerÕs disease (sAD). Given this fact, an...

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    [title] => A Neonatal Mild Defect in Brain Insulin Signaling Predisposes a Subclinical Mode
    [paragraph] => A Neonatal Mild Defect in Brain Insulin Signaling Predisposes a Subclinical Model of Sporadic Alzheimer's to Develop the Disease
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Authors
Z Abbasi, MMG Seno, M FereidoniÊ

 Lab
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
Journal
Journal of Molecular Neuroscience
Abstract
Brain insulin system dysfunction has been proposed as a key player in the pathogenesis of sporadic AlzheimerÕs disease (sAD). Given this fact, an adult rat model for sAD has been developed by intracerebroventricular injection of a subdiabetogenic streptozotocin dosage (icv-STZ). A low dose of icv-STZ in adult rats leads to a subclinical model of AlzheimerÕs disease. According to the brain developmental origin for sAD occurrence, the present study evaluated the effect of neonatal injection of icv-STZ on the development and progression of AlzheimerÕs disease later in the adult animals treated with a low dose of icv-STZ. Although no alteration was observed in the rats receiving an adult low dose of icv-STZ, these animals displayed cognitive deficits if they were also treated neonatally with icv-STZ. These impairments were associated with altered gene expression of insulin receptor, tau and choline acetyltransferase, along with increased astrocyte and dark neuron densities in the hippocampus. This study highlights neonatal brain insulin system dysfunction in the programming of brain insulin signaling sensitivity and provides more evidence for the developmental origin of sAD.
BIOSEB Instruments Used
Rotarod (BX-ROD),Aron Test or Four Plates Test (LE830)
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Rotarod provides an easy way to test the motor activity in rodents (mouse or rat) - an ideal solution for studying central nervous system damage, disease effects on motor activity, drugs administration, fatigue resistance, etc. Now even easier to use! The new touchscreen graphic user interface allows clear visualization of timing and speed for each lane. Change modes, adjust speed, and create protocols right from the main screen for greater flexibility with maximum functionality and usability

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The Aron test allows a quick characterization of putative anxiolytics compounds in naïve animals. A must for studying anxiety, drug screening and phenotyping.
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