Arthritis & Osteoarthritis - page 5 Scientific Publications

Latest publication 12/12/2019

Alterations of voluntary behavior in the course of disease progress and pharmaco

We described for the first time significant alterations of the voluntary behavior of the mice with CIA during the clinical periods, indicating that...

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    [title] => Alterations of voluntary behavior in the course of disease progress and pharmaco
    [paragraph] => Alterations of voluntary behavior in the course of disease progress and pharmacotherapy in mice with collagen-induced arthritis
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Authors
Y Oto, Y Takahashi, D Kurosaka, F Kato

 Lab
Center for Neuroscience of Pain, Jikei University School of Medicine, Minato-ku, Tokyo, Japan
Journal
Arthritis Research & Therapy
Abstract
We described for the first time significant alterations of the voluntary behavior of the mice with CIA during the clinical periods, indicating that the overall physical/motivational states and its circadian variation, as well as the specific preference to a certain environmental temperature, are modified in the mice with CIA, as observed in human patients. Some of these did not parallel with the conventional arthritis scores, particularly during the pharmacotherapy suggesting that mice with CIA show not only the peripheral symptoms but also the central consequences. The use of these approaches would also help clarify the biological mechanisms underlying physician-patient discordance in the assessment of RA.
BIOSEB Instruments Used
Thermal Place Preference, 2 Temperatures Choice Nociception Test (BIO-T2CT)

Keywords/Topics
Arthritis & Osteoarthritis; Joints
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An operator independent test to study pain thresholds in rodents (mouse and rat) by assessing temperature preference (thermal comfort zone) - a new tool for your analgesia/nociception research opening new fields of investigation, and an ideal solution for nociceptive and analgesic drugs screening. Now comes with a brand new software, allowing tracking activity and faster temperature transitions!

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