Cardiac function - page 3 Scientific Publications

Latest publication 01/24/2012

Huntington's disease knock-in male mice show specific anxiety-like behaviour and

Huntington's disease (HD) is a devastating genetic neurodegenerative disorder. Major depressive disorder and more generally mood disorders are a...

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    [title] => Huntington's disease knock-in male mice show specific anxiety-like behaviour and
    [paragraph] => Huntington's disease knock-in male mice show specific anxiety-like behaviour and altered neuronal maturation. 
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Authors
S. Orvoen, P. Pla, A. Gardier, F. Saudou, D. David. 

 Lab
Univ Paris-Sud, Faculté de Pharmacie, Châtenay-Malabry, France.
Journal
Neuroscience Letters
Abstract
Huntington's disease (HD) is a devastating genetic neurodegenerative disorder. Major depressive disorder and more generally mood disorders are a major component of the symptoms during the pre-motor symptomatic stages of the disease. We report here that knock-in Hdh(Q111) mice, an animal model of HD, that carry an expanded polyglutamine stretch in the mouse HD protein show an anxio-depressive-like phenotype prior to any impairment of the locomotor function. Strikingly, whereas females develop preferentially a depressive-like behaviour, males had an increased anxiety-like phenotype. Since adult hippocampal neurogenesis has been associated to the pathophysiology and treatment of depression, we investigated whether changes in behavioural phenotypes are associated with proliferation or maturation impairments. Whereas cell proliferation was not affected in knock-in Hdh(Q111) mice, a male-specific marked decrease in late maturation of newborn neurons was observed in the adult dentate gyrus. Together, our results highlight sex differences in both behaviour and adult neurogenesis in a knock-in model of HD.
BIOSEB Instruments Used
Forced Swimming Test: New FST DUAL SENSOR (BIO-FST-DSM)
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The new Forced Swimming Test system from Bioseb uses a dual approach:
Combining a double input from vibrations and video,
 the TYC (Train-Your-Computer) algorithm compares both inputs to determine the animal's behavior in real time, making results completely operator-independent.

Experiment manager, analysis module, replay possibilities and the TYC algorithm are some of the features that make FST DUAL SENSOR a very innovative and easy to use instrument for both mice or rats studies (up to 4 animals can be tested at a time), based on the famous Porsolt Test, or "behavioral despair" test

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