Motor Deficits - page 2 Scientific Publications

Latest publication 12/22/2014

Modeling Autism Spectrum Disorders Motor Deficits in Mice

The prevalence of deficit of motor deficits in Autism Spectrum Disorders (ASD) reaches 80 % leading several authors to consider the deficits as an...

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    [title] => Modeling Autism Spectrum Disorders Motor Deficits in Mice
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Authors
Pierre L. Roubertoux, Catherine Bartoli

 Lab
INSERM, Aix Marseille Université, France
Journal
Neuromethods
Abstract
The prevalence of deficit of motor deficits in Autism Spectrum Disorders (ASD) reaches 80 % leading several authors to consider the deficits as an associated syndrome. The deficit impacts the development resulting in a general motor delay. Different adult features are affected in patients that present hypotonia as the more frequent characteristics. Coordination is impaired as well as praxis. Balance deficits and gait particularities as toe-walking are reported but they reach a lower frequency. If ASD patients have a high probability to present at least one motor deficit, the same pattern of motor traits is not impacted similarly in the patients. This is the consequence of the heterogeneity of the diseases included in the ASD category. The awkwardness caused by these deficits and potential alleviation incite to analyze motor deficits in mice models of ASD. The chapter considers motor development modeling from birth to weaning and hypotonia and deficits in coordination, balance, and gait in adult.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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