Muscular system - page 3 Scientific Publications

Latest publication 06/11/2018

Development of novel NEMO-binding domain mimetics for inhibiting IKK and NF-κB a

Nuclear factor κB (NF-κB) is a transcription factor important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, and...

Array
(
    [id_prestablog_news] => 1031
    [id_shop] => 1
    [date] => 2018-06-11 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2023
    [id_lang] => 1
    [title] => Development of novel NEMO-binding domain mimetics for inhibiting IKK and NF-κB a
    [paragraph] => Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation
    [content] => 
Authors
J Zhao, L Zhang, X Mu, C Doebelin, et al.

 Lab
Department of Molecular Medicine and the TSRI Center on Aging, The Scripps Research Institute, Jupiter, Florida, United States of America 
Journal
PLOS Biology
Abstract
Nuclear factor κB (NF-κB) is a transcription factor important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, and senescence. Dysregulation of NF-κB and its upstream regulator IκB kinase (IKK) contributes to the pathogenesis of multiple inflammatory and degenerative diseases as well as cancer. An 11–amino acid peptide containing the NF-κB essential modulator (NEMO)-binding domain (NBD) derived from the C-terminus of β subunit of IKK, functions as a highly selective inhibitor of the IKK complex by disrupting the association of IKKβ and the IKKγ subunit NEMO. A structure-based pharmacophore model was developed to identify NBD mimetics by in silico screening. Two optimized lead NBD mimetics, SR12343 and SR12460, inhibited tumor necrosis factor α (TNF-α)- and lipopolysaccharide (LPS)-induced NF-κB activation by blocking the interaction between IKKβ and NEMO and suppressed LPS-induced acute pulmonary inflammation in mice. Chronic treatment of a mouse model of Duchenne muscular dystrophy (DMD) with SR12343 and SR12460 attenuated inflammatory infiltration, necrosis and muscle degeneration, demonstrating that these small-molecule NBD mimetics are potential therapeutics for inflammatory and degenerative diseases.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
    [meta_description] => 
    [meta_keywords] => http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004663
    [meta_title] => 
    [link_rewrite] => development-of-novel-nemo-binding-domain-mimetics-for-inhibiting-ikk-and-nf-b-activation
    [actif_langue] => 1
    [read] => 1264
    [count_comments] => 0
    [id] => 1031
    [categories] => Array
        (
            [24] => Array
                (
                    [id_prestablog_categorie] => 24
                    [title] => Cross-disciplinary subjects 
                    [link_rewrite] => Cross-disciplinary-subjects-
                )

            [44] => Array
                (
                    [id_prestablog_categorie] => 44
                    [title] => Duchenne muscular dystrophy
                    [link_rewrite] => Duchenne-muscular-dystrophy
                )

            [43] => Array
                (
                    [id_prestablog_categorie] => 43
                    [title] => General neurodegeneration
                    [link_rewrite] => General-neurodegeneration
                )

            [93] => Array
                (
                    [id_prestablog_categorie] => 93
                    [title] => Inflammation
                    [link_rewrite] => Inflammation
                )

            [20] => Array
                (
                    [id_prestablog_categorie] => 20
                    [title] => Muscular system
                    [link_rewrite] => Muscular-system
                )

            [12] => Array
                (
                    [id_prestablog_categorie] => 12
                    [title] => Neurodegeneration
                    [link_rewrite] => Neurodegeneration
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Grip strength test
                    [description_short] => 
An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/activity-motor-control-coordination/48-grip-strength-test.html
                )

        )

)
1