Nerve regeneration - page 3 Scientific Publications

Latest publication 04/08/2011

Passive and active exercise improve regeneration and muscle reinnervation after

INTRODUCTION: Lesions of peripheral nerves cause loss of motor and sensory function and also lead to hyperreflexia and hyperalgesia....

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    [title] => Passive and active exercise improve regeneration and muscle reinnervation after 
    [paragraph] => Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat. 
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Authors
E. Udina, A. Puigdemasa, X. Navarro. 

 Lab
Universitat Autònoma de Barcelona, Institute of Neurosciences and Department of Cell Biology, Group of Neuroplasticity and Regeneration, Bellaterra, Spain.
Journal
Muscle and Nerve
Abstract
INTRODUCTION: Lesions of peripheral nerves cause loss of motor and sensory function and also lead to hyperreflexia and hyperalgesia. Activity-dependent therapies promote axonal regeneration and functional recovery and may improve sensory-motor coordination and restoration of adequate circuitry at the spinal level. METHODS: We compared the effects of passive (bicycle) and active (treadmill) exercise on nerve regeneration and modulation of the spinal H reflex after transection and repair of the rat sciatic nerve. Animals were evaluated during 2 months using electrophysiological, functional, and histological methods. RESULTS: Moderate exercise for 1 hour/day, either active treadmill walking or passive cycling, improved muscle reinnervation, increased the number of regenerated axons in the distal nerve, and reduced the increased excitability of spinal reflexes after nerve lesion. DISCUSSION: Maintenance of denervated muscle activity and afferent input, by active or passive exercise, may increase trophic factor release to act on regenerating axons and to modulate central neuronal plasticity.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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