Neuropathic pain - page 11 Scientific Publications

Latest publication 12/15/2005

Assessment of nociception in acrylamide-induced neuropathy in rats-

Acrylamide was intraperitoneally administered to male Sprague-Dawley rats at four different doses (5, 10, 20 and 30 mg/kg) three times a week for 5...

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    [title] => Assessment of nociception in acrylamide-induced neuropathy in rats-
    [paragraph] => Assessment of nociception in acrylamide-induced neuropathy in rats.
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Authors
B. Ling, N. Authier, D. Balayssac, A. Eschalier, F. Coudore.

 Lab
Laboratoire de Pharmacologie-Toxicologie, CHU Gabriel-Montpied, Clermont-Ferrand, France.
Journal
Pain
Abstract
Acrylamide was intraperitoneally administered to male Sprague-Dawley rats at four different doses (5, 10, 20 and 30 mg/kg) three times a week for 5 consecutive weeks. Because of motor dysfunction, the 30 mg/kg dose was not used for behavioral pain tests. Clinical status remained good throughout the experiment and no motor deficit was observed at the other doses. We showed that acrylamide administration at low doses and cumulative dose (CD) range of 35–140 mg/kg produced mechanical allodynia and rapid, marked heat (42 °C) and cold (10 °C) allodynia after tail immersion test. Mechanical and thermal hyperalgesia appeared after higher cumulative doses (70–280 mg/kg), except for cold (4 °C) hyperalgesia (20–80 mg/kg). All the modifications persisted throughout all study, except the mechanical hyperalgia. All the cumulative doses tested were lower than those generally reported to induce motor dysfunction (CD>250 mg/kg), confirming that CD may be considered to be a suitable index in assessing neurological signs and suggesting that early detection of acrylamide neurotoxicity would be possible using the sensory tests, especially those for detecting allodynia thresholds.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Neuropathic pain; Pain
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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