Publications

Latest publication 03/21/2019

Amelioration of muscle wasting by glucagon_like peptide_1 receptor agonist in mu

Skeletal muscle atrophy is deÞned as a reduction of muscle mass caused by excessive protein degradation. However, the development of therapeutic...

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    [date] => 2019-03-21 00:00:00
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    [title] => Amelioration of muscle wasting by glucagon_like peptide_1 receptor agonist in mu
    [paragraph] => Amelioration of muscle wasting by glucagon_like peptide_1 receptor agonist in muscle atrophy
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Authors
Y Hong, JH Lee, KW Jeong, CS Choi, HS Jun

 Lab
 College of Pharmacy, Gachon University, 7 45 Songdo-dong, Yeonsu-ku, Incheon, 406 840 , Korea
Journal
Journal of Cachexia, Sarcopenia and Muscle 
Abstract
 Skeletal muscle atrophy is deÞned as a reduction of muscle mass caused by excessive protein degradation. However, the development of therapeutic interventions is still in an early stage. Although glucagon-like peptide-1 receptor (GLP1R) agonists, such as exendin-4 (Ex-4) and dulaglutide, are widely used for the treatment of diabetes, their effects on muscle pathology are unknown. In this study, we investigated the therapeutic potential of GLP-1R agonist for muscle wasting and the mechanisms involved. 
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Muscular atrophy; Muscular system
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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