Publications

Latest publication 12/14/2023

BACH1 changes microglial metabolism and affects astrogenesis during mouse brain

Summary Microglia are highly heterogeneous as resident immune cells in the central nervous system. Although the proinflammatory phenotype of...

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    [title] => BACH1 changes microglial metabolism and affects astrogenesis during mouse brain 
    [paragraph] => BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development
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Authors
Yanyan Wang, Wenwen Wang, Libo Su, Fen Ji, Mengtian Zhang, Yanzhen Xie, Tianyu Zhang, Jianwei Jiao

 Lab

Journal
Developmental Cell
Abstract
Summary
Microglia are highly heterogeneous as resident immune cells in the central nervous system. Although the proinflammatory phenotype of microglia is driven by the metabolic transformation in the disease state, the mechanism of metabolic reprogramming in microglia and whether it affects surrounding astrocyte progenitors have not been well elucidated. Here, we illustrate the communication between microglial metabolism and astrogenesis during embryonic development. The transcription factor BTB and CNC homology 1 (Bach1) reduces lactate production by inhibiting two key enzymes, HK2 and GAPDH, during glycolysis. Metabolic perturbation of microglia reduces lactate-dependent histone modification enrichment at the Lrrc15 promoter.The microglia-derived LRRC15 interacts with CD248 to participate in the JAK/STAT pathway and influence astrogenesis. In addition, Bach1cKO-Cx3 mice exhibit abnormal neuronal differentiation and anxiety-like behaviors. Altogether, this work suggests that the maintenance of microglia metabolic homeostasis during early brain development is closely related to astrogenesis, providing insights into astrogenesis and related diseases.

Keywords/Topics
BACH1 ;microglia; metabolism ;astrogenesis; histone; lactylation; LRRC15 I
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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