Publications

Latest publication 11/27/2021

Alverine citrate promotes myogenic differentiation and ameliorates muscle atroph

Sarcopenia is the age-related loss of muscle mass and function and no pharmacological medication has been approved for its treatment. We...

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    [date] => 2021-11-27 00:00:00
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    [title] => Alverine citrate promotes myogenic differentiation and ameliorates muscle atroph
    [paragraph] => Alverine citrate promotes myogenic differentiation and ameliorates muscle atrophy
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Authors
JH Yoon, SM Lee, Y Lee et al

 Lab
Aging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 1Yuseong-gu, Daejeon, Republic of Korea.
Journal
Biochemical and Biophysical Research Communications
Abstract
Sarcopenia is the age-related loss of muscle mass and function and no pharmacological medication has been approved for its treatment. We established an atrogin-1/MAFbx promoter assay to find drug candidates that inhibit myotube atrophy. Alverine citrate (AC) was identified using high-throughput screening of an existing drug library. AC is an established medicine for stomach and intestinal spasms. AC treatment increased myotube diameter and inhibited atrophy signals induced by either C26-conditioned medium or dexamethasone in cultured C2C12 myoblasts. AC also enhanced myoblast fusion through the upregulation of fusion-related genes during C2C12 myoblast differentiation. Oral administration of AC improves muscle mass and physical performance in aged mice, as well as hindlimb-disused mice. Taken together, our data suggest that AC may be a novel therapeutic candidate for improving muscle weakness, including sarcopenia.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Muscular atrophy
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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