Publications

Latest publication 08/26/2021

Wharton's Jelly-Derived Mesenchymal Stem Cells Reduce Fibrosis in a Mouse Model

The aim of this study was to evaluate the therapeutic effects and mechanisms of WhartonÕs jelly-derived mesenchymal stem cells (WJ-MSCs) in an...

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    [title] => Wharton's Jelly-Derived Mesenchymal Stem Cells Reduce Fibrosis in a Mouse Model 
    [paragraph] => Wharton's Jelly-Derived Mesenchymal Stem Cells Reduce Fibrosis in a Mouse Model of Duchenne Muscular Dystrophy by Upregulating MicroRNA 499
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Authors
SE Park, JB Jeong, SJ Oh et al

 Lab
Sungkyunkwan University School of Medicine, Seoul, Korea
Journal
Biomedicines 
Abstract
The aim of this study was to evaluate the therapeutic effects and mechanisms of WhartonÕs jelly-derived mesenchymal stem cells (WJ-MSCs) in an animal model of Duchenne muscular dystrophy (DMD). Mdx mice (3Ð5 months old) were administered five different doses of WJ-MSCs through their tail veins. A week after injection, grip strength measurements, creatine kinase (CK) assays, immunohistochemistry, and western blots were performed for comparison between healthy mice, mdx control mice, and WJ-MSC-injected mdx mice. WJ-MSCs exerted dose-dependent multisystem therapeutic effects in mdx mice, by decreasing CK, recovering normal behavior, regenerating muscle, and reducing apoptosis and fibrosis in skeletal muscle. We also confirmed that miR-499-5p is significantly downregulated in mdx mice, and that intravenous injection of WJ-MSCs enhanced its expression, leading to anti-fibrotic effects via targeting TGFbetaR 1 and 3. Thus, WJ-MSCs may represent novel allogeneic Òoff-the-shelfÓ cellular products for the treatment of DMD and possibly other muscle disorders.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Duchenne muscular dystrophy
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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