Neuropathic pain - page 3 Scientific Publications

Latest publication 12/08/2023

Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-In

Blood biomarkers, including neurofilament light chain (NfL), have garnered attention as potential indicators for chemotherapy-induced peripheral...

Array
(
    [id_prestablog_news] => 1912
    [id_shop] => 1
    [date] => 2023-12-08 00:00:00
    [date_modification] => 2024-05-10 10:06:46
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 3482
    [id_lang] => 1
    [title] => Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-In
    [paragraph] => Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced Peripheral Neuropathy- A Comparative Pilot Study with Oxaliplatin- Paclitaxel- Bortezomib- and Vincristine
    [content] => 
Authors
Balayssac D, Durif J, Lambert C, Dalbos C, Chapuy E, Etienne M, Demiot C, Busserolles J, Martin V, Sapin V.

 Lab
CNRS, INSERM, iGReD, Université Clermont Auvergne, Clermont-Ferrand, France.
Journal
Neuropathy
Abstract
Blood biomarkers, including neurofilament light chain (NfL), have garnered attention as potential indicators for chemotherapy-induced peripheral neuropathy (CIPN), a dose-limiting adverse effect of neurotoxic anticancer drugs. However, no blood biomarker has been established for routine application or translational research. This pilot study aimed to evaluate a limited panel of blood biomarkers in rat models of CIPN and their correlations with neuropathic pain. CIPN models were induced through repeated injections of oxaliplatin, paclitaxel, bortezomib, and vincristine. Electronic von Frey testing was used to assess tactile allodynia. Post anticancer injections, serum concentrations of 31 proteins were measured. Allodynia thresholds decreased in anticancer-treated animals compared to controls. No consistent modifications were observed in the biomarkers across CIPN models. The most noteworthy biomarkers with increased concentrations in at least two CIPN models were NfL (paclitaxel, vincristine), MCP-1, and RANTES (oxaliplatin, vincristine). Vincristine-treated animals exhibited strong correlations between LIX, MCP-1, NfL, and VEGF concentrations and tactile allodynia thresholds. No single biomarker can be recommended as a unique indicator of CIPN-related pain. Because of the study limitations (single dose of each anticancer drug, young animals, and single time measurement of biomarkers), further investigations are necessary to define the kinetics, specificities, and sensitivities of MCP-1, RANTES, and NfL. 

Keywords/Topics
Neuropathic pain
    [meta_description] => 
    [meta_keywords] => https://www.mdpi.com/2305-6304/11/12/1004
    [meta_title] => 
    [link_rewrite] => exploring-serum-biomarkers-for-neuropathic-pain-in-rat-models-of-chemotherapy-induced-peripheral-neuropathy--a-comparative-pilot-study-with-oxaliplatin--paclitaxel--bortezomib--and-vincristine
    [actif_langue] => 1
    [read] => 625
    [count_comments] => 0
    [id] => 1912
    [categories] => Array
        (
            [29] => Array
                (
                    [id_prestablog_categorie] => 29
                    [title] => Neuropathic pain
                    [link_rewrite] => Neuropathic-pain
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1859] => Array
                (
                    [name] => Electronic Von Frey - Wireless
                    [description_short] => 
A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/pain-mechanical-allodynia-hyperalgesia/1859-electronic-von-frey-4.html
                )

            [1860] => Array
                (
                    [name] => Electronic Von Frey 5 with embedded camera
                    [description_short] => 
As an electronic version of the classical Von Frey Filaments esthesiometer (or aesthesiometer), the latest evolution of Bioseb's Electronic Von Frey instrument for determining the mechanical sensitivity threshold in rodents (rats and mice) is a must-have instrument for your reseach on hyperalgesia and allodynia. By measuring and recording the force at which the animal exhibits a paw withdrawal reflex, pathologies related to sensory response and hyper- or hypo-aesthesia can be studied.

The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/pain-mechanical-allodynia-hyperalgesia/1860-electronic-von-frey-5-with-embedded-camera.html
                )

        )

)
1