Mechanical allodynia & Hyperlagesia - page 6 Scientific Publications

Latest publication 06/30/2008

Polyamine deficient diet to relieve pain hypersensitivity-

There is a compelling body of evidence that N-methyl-d-aspartate receptors (NMDA-R) play a critical role in the development and maintenance of pain...

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    [title] => Polyamine deficient diet to relieve pain hypersensitivity-
    [paragraph] => Polyamine deficient diet to relieve pain hypersensitivity.
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Authors
C. Rivat, P. Richebé, E. Laboureyras, J.-P. Laulin, R. Havouis et al.

 Lab
UMR CNRS 5227, “Mouvement-Adaptation-Cognition”, Team “Homéostasie-Allostasie-Pathologie-Réhabilitation”, Bordeaux, France.
Journal
Pain
Abstract
There is a compelling body of evidence that N-methyl-d-aspartate receptors (NMDA-R) play a critical role in the development and maintenance of pain hypersensitivity. However, long-term treatments with NMDA-R antagonists are limited by unacceptable side effects. Since polyamines modulate the functioning of NMDA-R and mainly originate from normal dietary intake and bacterial metabolism in the gut, we developed a nutritional therapy based on dietary polyamine deficiency. Here, we reported that a polyamine deficient diet (PD diet) for 7 days prevented the enhancement of tyrosine phosphorylation of the spinal NR2B subunit-containing NMDA-R associated with inflammation in rats. Based on these data, we studied the ability of PD diet to prevent long-lasting pain hypersensitivity associated with tissue injury on one hind paw by evaluating long-lasting changes in both mechanical nociceptive threshold and weight bearing. A PD diet strongly reduced long-lasting hyperalgesia induced by inflammation or incision, especially in fentanyl-treated rats. Moreover a PD diet also prevented the exaggerated hyperalgesia induced by a second inflammation performed 7 days after the first one. A PD diet also opposed paradoxical hyperalgesia induced by non-nociceptive environmental stress in rats with pain and opioid experiences. A PD diet reversed pain hypersensitivity associated with monoarthritis or neuropathy and restored the analgesic effect of morphine. Since PD diet was devoid of any noticeable side effects, this nutritional therapy could be part of an effective and safe strategy for pre-emptive analgesia and for reducing the transition from acute to chronic pain and its outcomes in various pain syndromes.
BIOSEB Instruments Used
Static Weight Bearing Touch: Incapacitance Test (BIO-SWB-TOUCH-M),Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)

Keywords/Topics
Mechanical allodynia & Hyperlagesia; Pain
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An easy and non pain-inducing solution for assessing the level of discomfort (incapacitance) in the injured paw of a small animal like a rat or a mouse by measuring the Postural Equilibrium “ independently of the operator". The static weight bearing instrument is ideal for your research on analagesia and nociception involving rodents: osteo arthrisis, cartilage degeneration, inflammation models, nerve injury models, and much more... Discover the SWB-Touch: now with a brand new touch-screen console!

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Developed in collaboration with Dr. Tighilet’s lab from Aix Marseille Université-CNRS, the Postural Module improves your DWB2, providing valuable endpoints for studies on pain, neurology, vestibular dysfunction, and neurodegenerative disorders.

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