Publications

Latest publication 01/20/2015

The Low Threshold Calcium Channel Cav3-2 Determines Low Threshold Mechanorecepto

The T-type calcium channel Cav3.2 emerges as a key regulator of sensory functions, but its expression pattern within primary afferent neurons and...

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    [title] => The Low Threshold Calcium Channel Cav3-2 Determines Low Threshold Mechanorecepto
    [paragraph] => The Low Threshold Calcium Channel Cav3.2 Determines Low Threshold Mechanoreceptor Function
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Authors
François A, Schüetter N, Laffray S, Sanguesa J et al

 Lab
Institut de Génomique Fonctionnelle, 141 rue de la Cardonille, 34094 Montpellier, France
Journal
Cell Reports
Abstract
The T-type calcium channel Cav3.2 emerges as a key regulator of sensory functions, but its expression pattern within primary afferent neurons and its contribution to modality-specific signaling remain obscure. Here, we elucidate this issue using a unique knockin/flox mouse strain wherein Cav3.2 is replaced by a functional Cav3.2-surface-ecliptic GFP fusion. We demonstrate that Cav3.2 is a selective marker of two major low-threshold mechanoreceptors (LTMRs), A_- and C-LTMRs, innervating the most abundant skin hair follicles. The presence of Cav3.2 along LTMR-fiber trajectories is consistent with critical roles at multiple sites, setting their strong excitability. Strikingly, the C-LTMR-specific knockout uncovers that Cav3.2 regulates light-touch perception and noxious mechanical cold and chemical sensations and is essential to build up that debilitates allodynic symptoms of neuropathic pain, a mechanism thought to be entirely A-LTMR specific. Collectively, our findings support a fundamental role for Cav3.2 in touch/pain pathophysiology, validating their critic pharmacological relevance to relieve mechanical and cold allodynia.
BIOSEB Instruments Used
Thermal Gradient Test (BIO-GRADIENT)
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