Publications

Latest publication 04/01/2014

Cav3- 2 calcium channels- the key protagonist of the supraspinal effect of para-

To exert its analgesic action, paracetamol requires complex metabolism to produce a brain-specific lipoamino acid compound, AM404, which targets...

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    [title] => Cav3- 2 calcium channels- the key protagonist of the supraspinal effect of para-
    [paragraph] => Cav3. 2 calcium channels: the key protagonist of the supraspinal effect of para-cetamol
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Authors
Kerckhove N, Mallet C, François A, Boudes M, Chemin J, Voets T, Bourinet E, Alloui A, Eschalier A

 Lab
Clermont Université, Université d'Auvergne, Pharmacologie Fondamentale et Clinique de la Douleur, 63000 Clermont-Ferrand, France
Journal
Pain. 
Abstract
To exert its analgesic action, paracetamol requires complex metabolism to produce a brain-specific lipoamino acid compound, AM404, which targets central transient receptor potential vanilloid receptors (TRPV1). Lipoamino acids are also known to induce analgesia through T-type calcium-channel inhibition (Ca(v)3.2). In this study we show that the antinociceptive effect of paracetamol in mice is lost when supraspinal Ca(v)3.2 channels are inhibited. Therefore, we hypothesized a relationship between supraspinal Ca(v)3.2 and TRPV1, via AM404, which mediates the analgesic effect of paracetamol. AM404 is able to activate TRPV1 and weakly inhibits Ca(v)3.2. Interestingly, activation of TRPV1 induces a strong inhibition of Ca(v)3.2 current. Supporting this, intracerebroventricular administration of AM404 or capsaicin produces antinociception that is lost in Ca(v)3.2(-/-) mice. Our study, for the first time, (1) provides a molecular mechanism for the supraspinal antinociceptive effect of paracetamol; (2) identifies the relationship between TRPV1 and the Ca(v)3.2 channel; and (3) suggests supraspinal Ca(v)3.2 inhibition as a potential pharmacological strategy to alleviate pain.
BIOSEB Instruments Used
Von Frey Filaments (Bio-VF-M)

Keywords/Topics
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