Publications

Latest publication 04/01/2025

Inhibition of SARM1 Reduces Neuropathic Pain in a Spared Nerve Injury Rodent Mod

WT Injury rats were more sensitive to pain than WT Sham at all postoperative time points, validating the pain model. Injured SARM1 KO rats only...

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    [title] => Inhibition of SARM1 Reduces Neuropathic Pain in a Spared Nerve Injury Rodent Mod
    [paragraph] => Inhibition of SARM1 Reduces Neuropathic Pain in a Spared Nerve Injury Rodent Model
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Authors
Christopher G. Herbosa, Ronald Perez, Alexandra Jaeger, Christopher J. Dy, David M. Brogan

 Lab

Journal
Muscle & Nerve
Abstract
WT Injury rats were more sensitive to pain than WT Sham at all postoperative time points, validating the pain model. Injured SARM1 KO rats only demonstrated a difference in mechanical or cold nociception from KO Sham at Week 3. Injured KO rats demonstrated a clear trend of decreased sensitivity compared to WT Injury nociception, reaching significance at Week 4 (p= 0.044). Injured KO rats showed attenuated sensitivity to cold allodynia relative to WT at Week 2 (p= 0.019). IHC revealed decreased macrophages in spared sural nerves of injured KO animals at 2 and 4 weeks, and the proximal portion of tibial/peroneal nerves at Week 2.
Keywords/Topics
inflammation; macrophages; nerve injury; neuropathic pain; SARM1
BIOSEB Instruments Used:
Electronic Von Frey - Wireless (BIO-EVF-WRS),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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