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Latest publication 01/30/2011

Episodic and chronic migraineurs are hypersensitive to thermal stimuli between m

OBJECTIVE: To determine if migraineurs have evidence of interictal cutaneous sensitisation. SUBJECTS AND METHODS: Thermal and mechanical pain...

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    [title] => Episodic and chronic migraineurs are hypersensitive to thermal stimuli between m
    [paragraph] => Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks.
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Authors
T.  Schwedt, M. Krauss, K. Frey, R.W. Gereau 4th. 



 Lab
Washington University School of Medicine, St Louis,USA.


Journal
Cephalagia


Abstract
OBJECTIVE: To determine if migraineurs have evidence of interictal cutaneous sensitisation. SUBJECTS AND METHODS: Thermal and mechanical pain thresholds in 20 episodic migraineurs, 20 chronic migraineurs, and 20 non-migraine control subjects were compared. Quantitative sensory testing was conducted when subjects had been migraine-free for at least 48_h. Heat, cold and mechanical pain thresholds, and heat and cold pain tolerance thresholds were measured. RESULTS: Thermal pain thresholds and thermal pain tolerance thresholds differed significantly by headache group (P_=_0.001). During the interictal period, episodic and chronic migraineurs were more sensitive to thermal stimulation than non-migraine controls. CONCLUSIONS: Interictal sensitisation may predispose the migraineur to development of headaches, may be a marker of migraine activity, and a target for treatment.
BIOSEB Instruments Used
Von Frey Filaments (Bio-VF-M)


Keywords/Topics
Miscellaneous research domains
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A set of 20 monofilaments based on the Semmes Weinstein monofilament set - featuring retractable filaments to protect the filament and allow the investigator to carry a few around in a pocket


Instrument for ratsInstrument for mice

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