Publications

Latest publication 02/10/2005

Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primar

The SHIRPA primary screen comprises 40 measures covering various reflexes and basic sensorimotor functions. This multi-test battery was used to...

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    [title] => Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primar
    [paragraph] => Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen.
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Authors
R. Lalonde, M. Dumont, M. Staufenbiel, C. Strazielle.

 Lab
Université de Rouen, Faculté de Médecine et de Pharmacie, INSERM U614, Rouen, France ; CHUM/St-Luc, Neuroscience Research Center, Montreal, Canada ; Novartis Institutes for Biomedical Research, Nervous System Research, Basel, Switzerland ; Université Henr
Journal
Behavioural Brain Research
Abstract
The SHIRPA primary screen comprises 40 measures covering various reflexes and basic sensorimotor functions. This multi-test battery was used to compare non-transgenic controls with APP23 transgenic mice, expressing the 751 isoform of human beta-amyloid precursor protein and characterized by amyloid deposits in parenchyma and vessel walls. The APP23 mice were distinguishable from controls by pathological limb reflexes, myoclonic jumping, seizure activity, and tail malformation. In addition, this mouse model of Alzheimer’s disease was also marked by a crooked swimming trajectory. APP23 mice were also of lighter weight and were less inclined to stay immobile during a transfer arousal test. Despite the neurologic signs, APP23 transgenic mice were not deficient in stationary beam, coat-hanger, and rotorod tests, indicating intact motor coordination abilities.
BIOSEB Instruments Used
Aron Test or Four Plates Test (LE830),Rotarod (BX-ROD)

Keywords/Topics
Phenotyping; Cross-disciplinary subjects 
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The Four Plates Test is an exclusivity from BIOSEB!
The Aron test allows a quick characterization of putative anxiolytics compounds in naïve animals. A must for studying anxiety, drug screening and phenotyping.
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Rotarod provides an easy way to test the motor activity in rodents (mouse or rat) - an ideal solution for studying central nervous system damage, disease effects on motor activity, drugs administration, fatigue resistance, etc. Now even easier to use! The new touchscreen graphic user interface allows clear visualization of timing and speed for each lane. Change modes, adjust speed, and create protocols right from the main screen for greater flexibility with maximum functionality and usability

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