Mechanical allodynia & Hyperlagesia - page 1 Scientific Publications

Latest publication 11/01/2025

Spinal p38 MAPK and PGC-1α and SIRT3 signaling pathway mediates remifentanil-

Remifentanil-induced hyperalgesia (RIH) poses a significant clinical challenge. Our research group has previously confirmed that abnormal...

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    [title] => Spinal p38 MAPK and PGC-1α and SIRT3 signaling pathway mediates remifentanil-
    [paragraph] => Spinal p38 MAPK and PGC-1α and SIRT3 signaling pathway mediates remifentanil-induced hyperalgesia in rats via ROS release and NR2B activation
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Authors
Guoyan Feng, Fengxiang Song, Aiqi Wang, Lu Wang, Haotian Zhang, Shun Wang, Haitao Hou, Lianxiang Zhang, Liqin Deng

 Lab

Journal
Neurochemistry International
Abstract
Remifentanil-induced hyperalgesia (RIH) poses a significant clinical challenge. Our research group has previously confirmed that abnormal activation o…
Keywords/Topics
pain;hyperalgesia
BIOSEB Instruments Used:
Electronic Von Frey - Wireless (BIO-EVF-WRS),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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As an electronic version of the classical Von Frey Filaments esthesiometer (or aesthesiometer), the latest evolution of Bioseb's Electronic Von Frey instrument for determining the mechanical sensitivity threshold in rodents (rats and mice) is a must-have instrument for your reseach on hyperalgesia and allodynia. By measuring and recording the force at which the animal exhibits a paw withdrawal reflex, pathologies related to sensory response and hyper- or hypo-aesthesia can be studied.

The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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