Neuropathic pain - page 3 Scientific Publications

Latest publication 02/24/2022

A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueduc

The hypothalamic neuropeptide, oxytocin (OT), exerts prominent analgesic effects via central and peripheral action. Here we discovered a novel...

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    [title] => A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueduc
    [paragraph] => A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray
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Authors
M Iwasaki, A Lefevre, F Althammer et al

 Lab
Centre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France
Journal
bioRxiv
Abstract
The hypothalamic neuropeptide, oxytocin (OT), exerts prominent analgesic effects via central and peripheral action. Here we discovered a novel subset of OT neurons whose projections preferentially terminate on OT receptor (OTR)-expressing neurons in the ventrolateral periaqueductal gray (vlPAG). Using a newly generated line of transgenic rats (OTR-IRES-Cre), we determined that most of the vlPAG OTR expressing cells being targeted by OT projections are GABAergic in nature. Both optogenetically-evoked axonal OT release in the vlPAG as well as chemogenetic activation of OTR vlPAG neurons results in a long-lasting overall increase of vlPAG neuronal activity. This then leads to an indirect suppression of sensory neuron activity in the spinal cord and strong analgesia. Finally, we describe a novel OT_vlPAG_spinal cord circuit that seems critical for analgesia in the context of both inflammatory and neuropathic pain.
BIOSEB Instruments Used
Rodent pincher - analgesia meter (BIO-RP-M)
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A fast and accurate algometer based on an instrumented pincher as an alternative to the Randall-Selitto test: This new analgesia meter developed by Bioseb following Luis-Delgado et al. (2005) allows accurate nociceptive tests to measure mechanical pain threshold on rat or mouse limbs with minimal constraint. Now wireless, to be free from annoying cables!

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