Other pathologies - page 3 Scientific Publications

Latest publication 02/17/2025

Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect

A study was conducted to evaluate the three-dimensional clinostat simulated microgravity effect on mouse models, focusing on the central nervous...

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    [title] => Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect
    [paragraph] => Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect in mice focusing on the central nervous system
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Authors
Zhou, Li, Song, Chenchen, Yang, Hu, Zhao, Lianlian, Li, Xianglei, Sun, Xiuping, Gao, Kai, Guo, Jianguo

 Lab

Journal
Scientific Reports
Abstract
A study was conducted to evaluate the three-dimensional clinostat simulated microgravity effect on mouse models, focusing on the central nervous system. Eighteen mice were divided into three groups: control, survival box, and clinostat + survival box. Behavioral tests, femur micro-CT, brain transcriptomics, serum metabolomics, and fecal microbiomics were performed. Results showed decreased activity, altered gait, enhanced fear memory, bone loss, immune/endocrine changes in brain transcriptome, and altered metabolic pathways in serum and gut microbiota in clinostat-treated mice. The model closely mimics spaceflight-induced transcriptome changes, suggesting its value in studying microgravity-related neurological alterations and highlighting the need for attention to emotional changes in space.
Keywords/Topics
Microgravity; Three-dimensional clinostat; Brain; Transcriptomics; Microbiomics; Serum metabolomics; Animal model; Environmental impact; Neuroscience; Physiology; Risk factors; Zoology
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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