Publications

Latest publication 10/15/2012

Comparison of evoked and non-evoked endpoints in a rodent pain model and potenti

The translational value of currently utilized animal pain models has been frequently debated ever since the clinical failure of the NK-1...

Array
(
    [id_prestablog_news] => 419
    [id_shop] => 1
    [date] => 2012-10-15 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 831
    [id_lang] => 1
    [title] => Comparison of evoked and non-evoked endpoints in a rodent pain model and potenti
    [paragraph] => Comparison of evoked and non-evoked endpoints in a rodent pain model and potential relevance to non-evoked human pain.
    [content] => 
Authors
D. L. Li, M.P. Johnson, J.D. Kennedy et al.

 Lab
Eli Lilly and Co., Indianapolis, USA
Journal
Society for Neuroscience 2012
Abstract
The translational value of currently utilized animal pain models has been frequently debated ever since the clinical failure of the NK-1 antagonists. While there are a number of reasons underlying failed clinical trials, a concern often noted is that evoked endpoints in rodent pain models do not accurately reflect on-going (non-evoked) pain as is most often reported in the clinic. Here we compare standard evoked endpoint measurements, including thermal hyperalgesia (Hargreaves test) and mechanical hypersensitivity (Randall-Selitto test) to dynamic weight bearing using the BIOSEB automated system in the context of the Carrageenan model of acute inflammation. Dynamic weight bearing averages a series of measures over time, eliminating potential subjectivity associated with standard static weight bearing/incapacitance testing. Since this test does not involve a noxious stimulus, changes in the weight animals place on the injured paw may reflect the level of on-going pain. NSAIDs are standard-of-care drugs for mild/moderate inflammatory pain and as well are effective in reversing evoked pain endpoints in the Carrageenan model. Drug doses less than the minimally efficacy doses (MED) for reversing evoked thermal or mechanical hypersensitivity were able to reverse Carrageenan-induced weight bearing deficits. These doses/systemic exposure more closely match effective doses/systemic exposures used in the treatment of human inflammatory pain. The use of non-evoked pain model endpoints such as dynamic weight bearing can provide a valuable means for evaluating on-going pain as part of a comprehensive behavioral pain model screening paradigm.
BIOSEB Instruments Used
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)

Keywords/Topics
Mechanical allodynia & Hyperlagesia; Pain
    [meta_description] => 
    [meta_keywords] => http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=0ee2f950-d506-4f76-98e9-cc462328b7b5&cKey=a3883daa-3f30-4ef2-bc14-1a2929942ec2&mKey={70007181-01C9-4DE9-A0A2-EEBFA14CD9F1}
    [meta_title] => 
    [link_rewrite] => comparison-of-evoked-and-non-evoked-endpoints-in-a-rodent-pain-model-and-potential-relevance-to-non-evoked-human-pain-
    [actif_langue] => 1
    [read] => 1610
    [count_comments] => 0
    [id] => 419
    [categories] => Array
        (
            [36] => Array
                (
                    [id_prestablog_categorie] => 36
                    [title] => Mechanical allodynia & Hyperlagesia
                    [link_rewrite] => Mechanical-allodynia-hyperlagesia
                )

            [10] => Array
                (
                    [id_prestablog_categorie] => 10
                    [title] => Pain
                    [link_rewrite] => Pain
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Comparison of evoked and non-evoked endpoints in a rodent pain model and potential relevance [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1216] => Array
                (
                    [name] => Dynamic Weight Bearing 2.0
                    [description_short] => 
The advanced version of our Dynamic Weight Bearing Test for rodents (rats and mice) allows for faster paw identification, based on a video solution taking advantage of the most advanced algorithms of morphologic analysis, weight distribution and postural changes in dynamic conditions. An efficient and advanced alternative to traditional incapacitance tests (i.e. the paw pressure test or the force plate test) for assessing pain sensitivity in your research on analgesia, hyperalgesia and nociception involving rats and mice, including work on osteoarthritis, bone cancer, analgesic substances, Parkinson disease, allodynia...

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/pain-spontaneous-pain-postural-deficit/1216-dynamic-weight-bearing-20.html
                )

            [1877] => Array
                (
                    [name] => Dynamic Weight Bearing 2.0 – Postural Module [Add-on]
                    [description_short] => 
Expand Your Analysis with Advanced Postural and Locomotor Calculations
BIOSEB’s renowned Dynamic Weight Bearing (DWB2) system is now more powerful than ever with the addition of the Postural Module. This optional software upgrade extends standard weight-bearing analysis by integrating unique calculations designed to quantify subtle aspects of postural balance, locomotor patterns, and compensatory behaviors.
Developed in collaboration with Dr. Tighilet’s lab from Aix Marseille Université-CNRS, the Postural Module improves your DWB2, providing valuable endpoints for studies on pain, neurology, vestibular dysfunction, and neurodegenerative disorders.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/pain-spontaneous-pain-postural-deficit/1877-dynamic-weight-bearing-20-add-on-postural-module.html
                )

        )

)
1