Publications

Latest publication 01/01/2024

Hypomethylation in promoters of PGC-1Alpha involved in exercise-driven skeletal

Exercise training can significantly improve skeletal muscle mitochondrial function and has been proven to be highly relevant to alterations in...

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    [title] => Hypomethylation in promoters of PGC-1Alpha involved in exercise-driven skeletal 
    [paragraph] => Hypomethylation in promoters of PGC-1Alpha involved in exercise-driven skeletal muscular alterations in old age
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Authors
Qiaowei Li, Qin Liu, Zhong Lin, Wenwen Lin, Feng Huang, Pengli Zhu

 Lab

Journal
Open Life Sciences
Abstract
Exercise training can significantly improve skeletal muscle mitochondrial function and has been proven to be highly relevant to alterations in skeletal muscle DNA methylation. However, it remains unclear whether late-in-life exercise has an effect on promoter methylation of PGC-1Alpha, a key regulator of mitochondrial biogenesis. Here we employed two distinct exercise modalities, constant medium intensity exercise training (CMIT) and high-intensity interval exercise training (HIIT), to investigate their impacts on PGC-1Alpha expression and methylation regulation in skeletal muscle of aged mice. The results revealed a notable decrease in PGC-1Alpha expression in skeletal muscle of aged mice, accompanied by elevated methylation levels of the PGC-1Alpha promoter, and increased DNA methyltransferase (DNMT) protein expressions. However, both forms of exercise training significantly corrected PGC-1Alpha epigenetic changes, increased PGC-1Alpha expression, and ameliorated skeletal muscle reduction. Furthermore, exercise training led to elevated expression of proteins related to mitochondrial biogenesis and energy metabolism in skeletal muscle, improving mitochondrial structure and function. In conclusion, late-in-life exercise improved skeletal muscle function, morphology, and mitochondria biogenesis, which may be associated with hypomethylation in promoters of PGC-1Alpha and increased content of skeletal muscle PGC-1Alpha. Notably, there was no clear difference between HIIT and CMIT in PGC-1Alpha expression and skeletal muscle function. Graphical abstract
Keywords/Topics
exercise ; PGC - 1 ; DNA methylation ; sarcopenia
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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