Publications

Latest publication 01/01/2022

Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the

Obesity is becoming a global epidemic and reversing the pathological processes underlying obesity and metabolic co-morbidities is challenging....

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    [title] => Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the 
    [paragraph] => Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis
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Authors
K Sundaram, J Mu, A Kumar et al

 Lab
James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
Journal
Theranostics
Abstract
Obesity is becoming a global epidemic and reversing the pathological processes underlying obesity and metabolic co-morbidities is challenging. Obesity induced chronic inflammation including brain inflammation is a hallmark of obesity via the gut-brain axis. The objective of this study was to develop garlic exosome-like nanoparticles (GaELNs) that inhibit systemic as well as brain inflammatory activity and reverse a HFD induced obesity in mice.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Obesity & Overweight
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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