Publications

Latest publication 08/31/2021

Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha and Be

Alpha/beta-hydrolase domain 6 (ABHD6) is an enzyme that hydrolyzes 2-arachidonoylglycerol, a high-efficiency endogenous cannabinoid. Although the...

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    [title] => Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha and Be
    [paragraph] => Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha and Beta-Hydrolase Domain 6 Knockout Rat
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Authors
K Noguchi, K Kadekawa, S Nishijima et al

 Lab
Southern Knights' Laboratory Co., Ltd., Chatan, Japan.
Journal
Cannabis and Cannabinoid
Abstract
Alpha/beta-hydrolase domain 6 (ABHD6) is an enzyme that hydrolyzes 2-arachidonoylglycerol, a high-efficiency endogenous cannabinoid. Although the endocannabinoid system has been suggested to be involved in regulation of bladder function, the roles of ABHD6 in the control of micturition remain unknown. To elucidate the physiological and pathological roles of ABHD6 in vivo, we examined phenotypes of ABHD6 knockout rats (Abhd6_/_) generated by clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins system.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)

Keywords/Topics
Mechanical allodynia & Hyperlagesia
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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