Publications

Latest publication 06/23/2011

Fluoxetine- Desipramine- and the Dual Antidepressant Milnacipran Reduce Alcohol

A few clinical studies have shown that dual antidepressants (serotonergic (5-HT) and noradrenergic (NE) transporter inhibitors, SNRIs) may be...

Array
(
    [id_prestablog_news] => 327
    [id_shop] => 1
    [date] => 2011-06-23 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 649
    [id_lang] => 1
    [title] => Fluoxetine- Desipramine- and the Dual Antidepressant Milnacipran Reduce Alcohol 
    [paragraph] => Fluoxetine, Desipramine, and the Dual Antidepressant Milnacipran Reduce Alcohol Self-Administration and/or Relapse in Dependent Rats. 
    [content] => 
Authors
E. Simon o'brien, R. Legastelois, H. Houchi, C. Vilpoux, S. Alaux-Cantin et al.

 Lab
Université de Picardie Jules Verne, Faculté de Pharmacie, Groupe de Recherche sur l’Alcool et les Pharmacodépendances , Amiens, France
Journal
Neuropsychopharmacology
Abstract
A few clinical studies have shown that dual antidepressants (serotonergic (5-HT) and noradrenergic (NE) transporter inhibitors, SNRIs) may be effective in alcoholism treatment. We studied the effect of the dual antidepressant milnacipran on ethanol operant self-administration in acutely withdrawn ethanol-dependent and in -non-dependent Wistar rats, and used fluoxetine and desipramine to dissect both 5-HT and NE components, respectively, in the effect of milnacipran. Milnacipran was also tested for relapse after protracted abstinence and on ethanol-induced (1.0_g/kg) conditioned place preference in control rats and ethanol-induced locomotor sensitization in DBA/2J female mice. Milnacipran dose dependently (5-40_mg/kg) attenuated the increased ethanol self-administration observed during early withdrawal and was more potent in preventing reinstatement in dependent rats after protracted abstinence as compared with non-dependent rats. Desipramine and fluoxetine (10_mg/kg) blocked ethanol self-administration during early withdrawal, and recovery was delayed in dependent animals, indicating a potent effect. Ethanol self-administration was also reduced 1 day after treatment with desipramine and fluoxetine but not with milnacipran. Finally, milnacipran prevented ethanol-induced place preference in ethanol-naive rats and reduced the magnitude of ethanol-induced sensitization associated with a delayed induction in mice. Desipramine (20_mg/kg) countered sensitization development and reduced its expression at 1 week after treatment; fluoxetine (10_mg/kg) reduced sensitization expression. Thus, 5-HT and NE transmissions during sensitization expression may mediate the effect of milnacipran on sensitization induction. These results support that SNRIs may have a potential use in alcoholism treatment.
BIOSEB Instruments Used
Infrared Actimeter (LE8815)

Keywords/Topics
Miscellaneous research domains
    [meta_description] => 
    [meta_keywords] => http://www.nature.com/npp/journal/v36/n7/full/npp201137a.html
    [meta_title] => 
    [link_rewrite] => fluoxetine--desipramine--and-the-dual-antidepressant-milnacipran-reduce-alcohol-self-administration-and-and-or-relapse-in-dependent-rats--
    [actif_langue] => 1
    [read] => 1222
    [count_comments] => 0
    [id] => 327
    [categories] => Array
        (
            [26] => Array
                (
                    [id_prestablog_categorie] => 26
                    [title] => Miscellaneous research domains
                    [link_rewrite] => Miscellaneous-research-domains
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Fluoxetine, Desipramine, and the Dual Antidepressant Milnacipran Reduce Alcohol [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [51] => Array
                (
                    [name] => Infrared Actimeter
                    [description_short] => Used to Measure SPONTANEOUS motor activity in an open field by mean of  photoelectric Infra Red beams
                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/activity-motor-control-coordination/51-infrared-actimeter.html
                )

        )

)
1