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Latest publication 11/23/2018

GLS1 mutant mice display moderate alterations of hippocampal glutamatergic neuro

Significant alterations in glutamatergic neurotransmission have been reported in major depressive disorder (MDD) that could underlie psychiatric...

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    [title] => GLS1 mutant mice display moderate alterations of hippocampal glutamatergic neuro
    [paragraph] => GLS1 mutant mice display moderate alterations of hippocampal glutamatergic neurotransmission associated with specific adaptive behavioral changes
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Authors
P Dutar, V Tolle, M Kervern, C Carcenac, V Carola

 Lab
NSERM UMU839, Institut du Fer à Moulin, Paris 75005 France Sorbonne Université, France.
Journal
Neuroscience
Abstract
Significant alterations in glutamatergic neurotransmission have been reported in major depressive disorder (MDD) that could underlie psychiatric traits. Studies were mainly interested in synaptic dysfunction in the prefrontal cortex, a key structure involved in depressive-like behavior, however hippocampus has been shown to be important in MDD. As cognitive deficits such as hippocampus-memory process were observed in MDD, we investigated in a mild hypoglutamatergic model behaviors related to depression and memory, synaptic transmission parameters and glutamatergic state specifically in the hippocampus. We thus characterized these phenotypes in adult male mice partially depleted in glutaminase type 1 or GLS1 (GLS1 HET), the enzyme responsible for glutamate synthesis in neurons, that we previously characterized as displaying moderate lower levels of glutamate in brain. We showed that GLS1 mutant mice display AMPA-R-mediated response deficits after prolonged repetitive stimulation with electrophysiological recording and inability to sustain glutamate release by microdialysis experiments with no consequences on behavioral spatial learning performances. However, their ability to escape from unpleasant but repeated escapable condition was attenuated whereas they were more immobile in the unescapable situation in the FST during re-test. These results show that GLS1 mutant mice display moderate impairments of hippocampal glutamatergic neurotransmission and moderate changes in adaptive behaviors that have been shown to participate to the development of depressive-like state.
BIOSEB Instruments Used
Tail Suspension Test - Wireless (BIO-TST5)
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Bioseb's version 5 of the Tail Suspension Test system, based on both strain sensors and video acquisition, is the only fully automatic solution in the world for running a simple and objective despair test on mice. It is a fast, painless, and reliable way for testing psychotropic effects from stimulant doses of drugs such as anti-depressants and sedatives. This classic and painless research test for anxiety and depression is now offered with a new, powerful and modern software, in a wireless, bluetooth-based version.

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