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Latest publication 10/05/2015

A novel GABA A alpha 5 receptor inhibitor with therapeutic potential

Novel 2,3-benzodiazepine and related isoquinoline derivatives, substituted at position 1 with a 2-benzothiophenyl moiety, were synthesized to...

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    [title] => A novel GABA A alpha 5 receptor inhibitor with therapeutic potential
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Authors
Ling I, Mihalik B, Etherington LA, Kapus G, Pálvölgyi A, Gigler G et al.



 Lab
Chemical Research Division, Egis Pharmaceuticals PLC, Budapest, Hungary.


Journal
Eur J Pharmacol.


Abstract
Novel 2,3-benzodiazepine and related isoquinoline derivatives, substituted at position 1 with a 2-benzothiophenyl moiety, were synthesized to produce compounds that potently inhibited the action of GABA on heterologously expressed GABAA receptors containing the alpha 5 subunit (GABAA ?5), with no apparent affinity for the benzodiazepine site. Substitutions of the benzothiophene moiety at position 4 led to compounds with drug-like properties that were putative inhibitors of extra-synaptic GABAA ?5 receptors and had substantial blood-brain barrier permeability. Initial characterization in vivo showed that 8-methyl-5-[4-(trifluoromethyl)-1-benzothiophen-2-yl]-1,9-dihydro-2H-[1,3]oxazolo[4,5-h][2,3]benzodiazepin-2-one was devoid of sedative, pro-convulsive or motor side-effects, and enhanced the performance of rats in the object recognition test. In summary, we have discovered a first-in-class GABA-site inhibitor of extra-synaptic GABAA ?5 receptors that has promising drug-like properties and warrants further development.
BIOSEB Instruments Used
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Keywords/Topics
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