Publications

Latest publication 08/19/2015

Early treatment with atorvastatin exerts parenchymal and vascular protective eff

BACKGROUND AND PURPOSE: From the clinical and experimental data available, statins appear to be interesting drug candidates for preventive...

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    [title] => Early treatment with atorvastatin exerts parenchymal and vascular protective eff
    [paragraph] => Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischemia
    [content] => 
Authors
Potey C, Ouk T, Petrault O, Petrault M, Berezowski V, Salleron J, Bordet R, Gautier S

 Lab
Medical Pharmacology Department, Faculty of Medicine, University of Lille 2 - Lille University Hospital, Lille, France.
Journal
Br J Pharmacol. 
Abstract
BACKGROUND AND PURPOSE:
From the clinical and experimental data available, statins appear to be interesting drug candidates for preventive neuroprotection in ischaemic stroke. However, their acute protective effect is, as yet, unconfirmed.

EXPERIMENTAL APPROACH:
Male C57Bl6/JRj mice were subjected to middle cerebral artery occlusion and treated acutely with atorvastatin (10-20 mg·kg-1 day-1 ; 24 or 72 h). Functional recovery (neuroscore, forelimb gripping strength and adhesive removal test) was assessed during follow-up and lesion volume measured at the end. Vasoreactivity of the middle cerebral artery (MCA), type IV collagen and FITC-dextran distribution were evaluated to assess macrovascular and microvascular protection. Activated microglia, leucocyte adhesion and infiltration were chosen as markers of inflammation.

KEY RESULTS:
Acute treatment with atorvastatin provided parenchymal and cerebral protection only at the higher dose of 20 mg·kg-1 ·day-1 . In this treatment group, functional recovery was ameliorated, and lesion volumes were reduced as early as 24 h after experimental stroke. This was associated with vascular protection as endothelial function of the MCA and the density and patency of the microvascular network were preserved. Acute atorvastatin administration also induced an anti-inflammatory effect in association with parenchymal and vascular mechanisms; it reduced microglial activation, and decreased leucocyte adhesion and infiltration.

CONCLUSIONS AND IMPLICATIONS:
Acute atorvastatin provides global cerebral protection, but only at the higher dose of 20 mg·kg-1 ·day-1 ; this was associated with a reduction in inflammation in both vascular and parenchymal compartments. Our results suggest that atorvastatin could also be beneficial when administered early after stroke.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Amyotrophic Lateral Sclerosis (ALS); Muscular system
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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