Publications

Latest publication 10/19/2021

Loss of REDD1 prevents chemotherapy-induced muscle atrophy and weakness in mice

Chemotherapy is an essential treatment to combat solid tumours and mitigate metastasis. Chemotherapy causes side effects including muscle wasting...

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    [title] => Loss of REDD1 prevents chemotherapy-induced muscle atrophy and weakness in mice
    [paragraph] => Loss of REDD1 prevents chemotherapy-induced muscle atrophy and weakness in mice
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Authors
BA Hain, H Xu, DL Waning 

 Lab
Dept. of Cellular and Molecular Physiology, The Penn State College of Medicine, Hershey, PA, USA
Journal
Journal of Cachexia, Sarcopenia and Muscle
Abstract
 Chemotherapy is an essential treatment to combat solid tumours and mitigate metastasis. Chemotherapy causes side effects including muscle wasting and weakness. Regulated in Development and DNADamage Response 1 (REDD1) is a stress-response protein that represses the mechanistic target of rapamycin (mTOR) in complex 1 (mTORC1), and its expression is increased in models of muscle wasting. The aim of this study was to determine if deletion of REDD1 is sufficient to attenuate chemotherapy-induced muscle wasting and weakness in mice.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Muscular atrophy; Cancer
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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