Publications

Latest publication 03/27/2026

Separating food intake-dependent and -independent effects in cancer cachexia

Summary Cancer cachexia is characterized by involuntary weight loss and wasting of fat and muscle, with diminished food intake commonly cited as...

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    [title] => Separating food intake-dependent and -independent effects in cancer cachexia
    [paragraph] => Separating food intake-dependent and -independent effects in cancer cachexia
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Authors
Yanshan Liang, Young-Yon Kwon, Sheng Hui

 Lab

Journal
iScience
Abstract
Summary
Cancer cachexia is characterized by involuntary weight loss and wasting of fat and muscle, with diminished food intake commonly cited as a cause. However, the extent to which reduced food intake drives these symptoms, and other phenotypes such as physical weakness, remains unclear. Using the colon carcinoma 26 (C26) mouse model, we assessed the role of food intake in key cachexia phenotypes. We found that reduced food intake was the predominant driver of body weight loss and tissue wasting, suggesting no additional causal mechanisms. In contrast, food intake reduction did not affect physical performance, indicating food intake-independent factors in causing weakness. Thus, depending on the model or patient group, reduced food intake may primarily drive some cachectic phenotypes while having no role in others. Discriminating between food intake-mediated effects and those independent of it is critical for guiding research focus and unraveling the causal pathways of cancer cachexia.

Keywords/Topics
Nutrition; Physiology; Cancer
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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