Publications

Latest publication 03/04/2015

Impaired Thermosensation in Mice Lacking TRPV3- a Heat and Camphor Sensor in the

Environmental temperature is thought to be directly sensed by neurons through their projections in the skin. A subset of the mammalian transient...

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    [title] => Impaired Thermosensation in Mice Lacking TRPV3- a Heat and Camphor Sensor in the
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Authors
Aziz Moqrich, Sun Wook Hwang, Taryn J. Earley et al.

 Lab
Department of Cell Biology, Scripps Research Insti- tute, La Jolla, CA 92037, USA
Journal
Science
Abstract
Environmental temperature is thought to be directly sensed by neurons through their projections in the skin. A subset of the mammalian transient receptor potential (TRP) family of ion channels has been implicated in this process. These ‘‘thermoTRPs’’ are activated at distinct temperature thresholds and are typically expressed in sensory neurons. TRPV3 is activated by heat (933-C) and, unlike most thermoTRPs, is expressed in mouse keratinocytes. We found that TRPV3 null mice have strong deficits in responses to innocuous and noxious heat but not in other sensory modalities; hence, TRPV3 has a specific role in thermosensation. The natural compound camphor, which modulates sensations of warmth in humans, proved to be a specific activator of TRPV3. Camphor activated cultured primary keratinocytes but not sensory neurons, and this activity was abolished in TRPV3 null mice. Therefore, heat-activated receptors in keratinocytes are important for mammalian thermosensation.
BIOSEB Instruments Used
Thermal Gradient Test (BIO-GRADIENT)
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The operator-independant Thermal Gradient Test is a new analgesia/nociceptive research instrument to demonstrate place preference / temperature comfort threshold on rodents (mouse and rat) freely moving on a plate offering a temperature gradient - an innovative tool for analgesic drug screening and research on thermal nociception.

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