Publications

Latest publication 02/01/2025

Ageing-Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incis

Mechanical head-withdrawal reflex threshold (MHWRT) of the palatal mucosa was measured for 21 days after palatal mucosal incision. On days 3...

Array
(
    [id_prestablog_news] => 2021
    [id_shop] => 1
    [date] => 2025-02-01 00:00:00
    [date_modification] => 2025-02-01 00:00:00
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 3704
    [id_lang] => 1
    [title] => Ageing-Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incis
    [paragraph] => Ageing-Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incisional Intraoral Pain
    [content] => 
Authors
Kentaro Urata, Tatsuki Oto, Yoshinori Hayashi, Suzuro Hitomi, Takayuki Ikeda, Koichi Iwata, Toshimitsu Iinuma, Masamichi Shinoda

 Lab

Journal
Oral Diseases
Abstract
Mechanical head-withdrawal reflex threshold (MHWRT) of the palatal mucosa was measured for 21 days after palatal mucosal incision. On days 3 and 14, the abundance of Iba-1-immunoreactive (IR) cells, CD11c-IR cells (pro-inflammatory macrophages (M1)), C-C motif chemokine ligand 2 (CCL2)-IR M1-macrophages, CD206-IR cells (anti-inflammatory macrophages (M2)) and transforming growth factor-β (TGF-β)-IR M2-macrophages in the TG was analysed. The effect of continuous intra-TG administration of CCL2-neutralising antibody or recombinant-CCL2 on MHWRT was examined.
Keywords/Topics
ageing; CCL2; intraoral mucosa; macrophage; mechanical pain hypersensitivity; trigeminal ganglion
BIOSEB Instruments Used:
Electronic Von Frey - Wireless (BIO-EVF-WRS),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
    [meta_description] => 
    [meta_keywords] => https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.15165
    [meta_title] => 
    [link_rewrite] => Ageing-Related-Macrophage-Polarisation-in-the-Trigeminal-Ganglion-Enhances-Incisional-Intraoral-Pain
    [actif_langue] => 1
    [read] => 16
    [count_comments] => 0
    [id] => 2021
    [categories] => Array
        (
            [27] => Array
                (
                    [id_prestablog_categorie] => 27
                    [title] => General pain
                    [link_rewrite] => General-pain
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Ageing-Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incisional Intraoral Pain
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1859] => Array
                (
                    [name] => Electronic Von Frey - Wireless
                    [description_short] => 
A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/pain-mechanical-allodynia-hyperalgesia/1859-electronic-von-frey-4.html
                )

            [1860] => Array
                (
                    [name] => Electronic Von Frey 5 with embedded camera
                    [description_short] => 
As an electronic version of the classical Von Frey Filaments esthesiometer (or aesthesiometer), the latest evolution of Bioseb's Electronic Von Frey instrument for determining the mechanical sensitivity threshold in rodents (rats and mice) is a must-have instrument for your reseach on hyperalgesia and allodynia. By measuring and recording the force at which the animal exhibits a paw withdrawal reflex, pathologies related to sensory response and hyper- or hypo-aesthesia can be studied.

The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/pain-mechanical-allodynia-hyperalgesia/1860-electronic-von-frey-5-with-embedded-camera.html
                )

        )

)
1