Publications

Latest publication 03/01/2026

Polymeric nanoparticle-mediated GBA1 gene therapy is neuroprotective in a precli

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia

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    [title] => Polymeric nanoparticle-mediated GBA1 gene therapy is neuroprotective in a precli
    [paragraph] => Polymeric nanoparticle-mediated GBA1 gene therapy is neuroprotective in a preclinical model of Parkinson’s disease
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Authors
Kwatra, Mohit, Kwak, Gijung, Li, Haolin, Suk, Jung Soo, Ko, Han Seok



 Lab


Journal
Drug Delivery and Translational Research


Abstract
Parkinson’s disease (PD) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia


Keywords/Topics
Glucocerebrosidase 1; GCase; Αlpha-synuclein; Intracranial gene therapy; Convection-enhanced delivery; Polymeric nanoparticle; Neuroprotection; Neuroinflammation
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.


New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)


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