Publications

Latest publication 04/01/2018

Modulation of the NGF–TRKA pathway for treatment of joint pain- preclinical in v

Chronic joint pain with pain at walking as major complaint affects a large portion of an aging population. Treatment options for this pain are...

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    [title] => Modulation of the NGF–TRKA pathway for treatment of joint pain- preclinical in v
    [paragraph] => Modulation of the NGF–TRKA pathway for treatment of joint pain: preclinical in vivo evaluation in mice
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Authors
K. Ängeby Möller, P. Forsell, G. Nordvall, J. Sandin, C.I. Svensson

 Lab
Karolinska Institute, Stockholm, Sweden
Journal
Osteoarthritis and Cartilage
Abstract
Chronic joint pain with pain at walking as major complaint affects a large portion of an aging population. Treatment options for this pain are insufficient, with side effects and less than full efficacy. Lack of predictive power for drug effects has been a major criticism against animal pain models and readouts. Using gait analysis and weight bearing in rats with monoarthritis induced by Freund's complete adjuvant (CFA), we have previously shown effects when interfering with the cyclooxygenase (COX) and nerve growth factor (NGF) pathways, whereas a TRPV1 inhibitor was ineffective.
BIOSEB Instruments Used
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)
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