Publications

Latest publication 03/19/2022

Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal mus

Sarcopenic obesity is a highly prevalent disease with poor survival and ineffective medical interventions. Mitochondrial dysfunction is purported...

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    [date] => 2022-03-19 00:00:00
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    [title] => Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal mus
    [paragraph] => Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control
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Authors
WS Dantas, ERM Zunica, EC Heintz et al

 Lab
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Journal
Journal of Cachexia, Sarcopenia and Muscle
Abstract
Sarcopenic obesity is a highly prevalent disease with poor survival and ineffective medical interventions. Mitochondrial dysfunction is purported to be central in the pathogenesis of sarcopenic obesity by impairing both organelle biogenesis and quality control. We have previously identified that a mitochondrial-targeted furazano[3,4-b]pyrazine named BAM15 is orally available and selectively lowers respiratory coupling efficiency and protects against diet-induced obesity in mice. Here, we tested the hypothesis that mitochondrial uncoupling simultaneously attenuates loss of muscle function and weight gain in a mouse model of sarcopenic obesity.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Obesity & Overweight
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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