Publications

Latest publication 07/29/2017

ADAMTS_4 in oligodendrocytes contributes to myelination with an impact on motor

Myelination is a late developmental process regulated by a set of inhibitory and stimulatory factors, including extracellular matrix components....

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    [title] => ADAMTS_4 in oligodendrocytes contributes to myelination with an impact on motor 
    [paragraph] => ADAMTS_4 in oligodendrocytes contributes to myelination with an impact on motor function
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Authors
M Pruvost, M Lepine, C Leonetti, O Etard, M Naveau, V Agin, F Docagne, E Maubert, C Ali, E Emery, D Vivien

 Lab
Physiopathology and imaging of Neurological disorders, GIP CYCERON, University of Caen Normandie, Bd Becquerel, BP 5229, 14074 Caen Cedex, France. 
Journal
Glia
Abstract
Myelination is a late developmental process regulated by a set of inhibitory and stimulatory factors, including extracellular matrix components. Accordingly, chondroitin sulfate proteoglycans (CSPGs) act as negative regulators of myelination processes. A disintegrin and metalloproteinase with thrombospondin motifs type 4 (ADAMTS_4) is an extracellular protease capable of degrading CSPGs. Although exogenous ADAMTS_4 has been proven to be beneficial in several models of central nervous system (CNS) injuries, the physiological functions of endogenous ADAMTS_4 remain poorly understood. We first used Adamts4/LacZ reporter mice to reveal that ADAMTS_4 is strongly expressed in the CNS, especially in the white matter, with a cellular profile restricted to mature oligodendrocytes. Interestingly, we evidenced an abnormal myelination in Adamts4_/_ mice, characterized by a higher diameter of myelinated axons with a shifting g_ratio. Accordingly, lack of ADAMTS_4 is accompanied by motor deficits and disturbed nervous electrical activity. In conclusion, we demonstrate that ADAMTS_4 is a new marker of mature oligodendrocytes contributing to the myelination processes and thus to the control of motor capacities.
BIOSEB Instruments Used
Aron Test or Four Plates Test (LE830),Rotarod (BX-ROD)
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The Four Plates Test is an exclusivity from BIOSEB!
The Aron test allows a quick characterization of putative anxiolytics compounds in naïve animals. A must for studying anxiety, drug screening and phenotyping.
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