Publications

Latest publication 04/18/2014

cGMP-dependent protein kinase type II knockout mice exhibit working memory impai

Neuronal activity regulates AMPA receptor trafficking, a process that mediates changes in synaptic strength, a key component of learning and...

Array
(
    [id_prestablog_news] => 587
    [id_shop] => 1
    [date] => 2014-04-18 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 1149
    [id_lang] => 1
    [title] => cGMP-dependent protein kinase type II knockout mice exhibit working memory impai
    [paragraph] => cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, decreased repetitive behavior, and increased anxiety-like traits
    [content] => 
Authors
C. M. Wincott, S. Abera, S. A. Vunck, N. Tirko, Y. Choi et al.

 Lab
New York University School of Medicine, New York, USA
Journal
Neurobiology of Learning and Memory
Abstract
Neuronal activity regulates AMPA receptor trafficking, a process that mediates changes in synaptic strength, a key component of learning and memory. This form of plasticity may be induced by stimulation of the NMDA receptor which, among its activities, increases cyclic guanosine monophosphate (cGMP) through the nitric oxide synthase pathway. cGMP-dependent protein kinase type II (cGKII) is ultimately activated via this mechanism and AMPA receptor subunit GluA1 is phosphorylated at serine 845. This phosphorylation contributes to the delivery of GluA1 to the synapse, a step that increases synaptic strength. Previous studies have shown that cGKII-deficient mice display striking spatial learning deficits in the Morris Water Maze compared to wild-type littermates as well as lowered GluA1 phosphorylation in the postsynaptic density of the prefrontal cortex ( and ). In the current study, we show that cGKII knockout mice exhibit impaired working memory as determined using the prefrontal cortex-dependent Radial Arm Maze (RAM). Additionally, we report reduced repetitive behavior in the Marble Burying task (MB), and heightened anxiety-like traits in the Novelty Suppressed Feeding Test (NSFT). These data suggest that cGKII may play a role in the integration of information that conveys both anxiety-provoking stimuli as well as the spatial and environmental cues that facilitate functional memory processes and appropriate behavioral response.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
    [meta_description] => 
    [meta_keywords] => http://www.sciencedirect.com/science/article/pii/S1074742714000689
    [meta_title] => 
    [link_rewrite] => cgmp-dependent-protein-kinase-type-ii-knockout-mice-exhibit-working-memory-impairments--decreased-repetitive-behavior--and-increased-anxiety-like-traits
    [actif_langue] => 1
    [read] => 1060
    [count_comments] => 0
    [id] => 587
    [categories] => Array
        (
            [56] => Array
                (
                    [id_prestablog_categorie] => 56
                    [title] => Anxiety
                    [link_rewrite] => Anxiety
                )

            [60] => Array
                (
                    [id_prestablog_categorie] => 60
                    [title] => Cognitive performance
                    [link_rewrite] => Cognitive-performance
                )

            [15] => Array
                (
                    [id_prestablog_categorie] => 15
                    [title] => Mood disorders
                    [link_rewrite] => Mood-disorders
                )

            [16] => Array
                (
                    [id_prestablog_categorie] => 16
                    [title] => Other disorders
                    [link_rewrite] => Other-disorders
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Grip strength test
                    [description_short] => 
An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/activity-motor-control-coordination/48-grip-strength-test.html
                )

        )

)
1